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. Author manuscript; available in PMC: 2024 Apr 1.
Published in final edited form as: Alzheimers Dement. 2023 Jan 13;19(4):1579–1586. doi: 10.1002/alz.12905

Figure 2. Emerging hypotheses of mechanisms connecting dual decline and impairment to future risk.

Figure 2.

The accumulating burden of ADRD pathologies outside the cerebrum may be sufficient to account for motor impairment and serve as a proxy for a higher burden of total CNS pathologies.