Table 3.
Results of the meta-analysis (a positive effect size value means an advantage in test group)
| 3 months | 6 months | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Mean [95% CI] (n° of studies) | P | I2 | Certainty of evidence (GRADE) | Mean [95% CI] (n° of studies) | P | I2 | Certainty of evidence (GRADE) | ||
| NSPT (with or without placebo) vs NSPT + Photodynamic therapy | PD red | 0.04 [− 0.13, 0.22] (6) | 0.63 | 93% | Very low | 0.26 [0.01, 0.50] (4) | 0.04 | 57% | Low |
| CAL gain | 0.03 [0.00, 0.06] (7) | 0.08 | 0% | Low | − 0.20 [− 0.23, − 0.17] (4) | < 0.001 | 0% | Moderate | |
| BOP% red | − 5.95 [− 9.92, − 1.98] (5) | 0.003 | 0% | Moderate | 0.36 [− 9.53, 10.25] (3) | 0.94 | 0% | Low | |
| PI red | 0.09 [− 0.08, 0.26] (3) | 0.32 | 79% | Very low | |||||
| PI% red | 0.23 [− 5.48, 5.95] (5) | 0.94 | 63% | Very low | 1.64 [− 3.78, 7.06] (3) | 0.55 | 0% | Very low | |
| HbA1c red | 0.24 [0.17, 0.32] (6) | < 0.001 | 14% | Moderate | − 0.04 [− 0.17, 0.10] (4) | 0.62 | 8% | Low | |
| NSPT (with or without placebo) vs NSPT + diode laser | PD red | 0.59 [0.41, 0.76] (4) | < 0.001 | 80% | Low | ||||
| CAL gain | 0.84 [0.09, 1.59] (3) | 0.03 | 86% | Low | |||||
| GI red | 0.34 [0.21, 0.47] (3) | < 0.001 | 0% | Moderate | |||||
| PI red | 0.21 [− 0.01, 0.43] (3) | 0.06 | 40% | Very low | |||||
| HbA1c red | 0.18 [0.07, 0.28] (4) | < 0.001 | 0% | Moderate | |||||
In bold the effect sizes that resulted statistically significant