Table 4:
Associations Between Individual OPE Urinary Metabolites (ng/mL) and Birthweight for Gestational Age (BW for GA) Z-scores
| Full Unadjusted Models β (95% CI) (N=421) | Full Adjusted Modelsa β (95% CI) (N=421) | Metabolite and Infant Sex Interaction P-value (N=421) | Female Only Adjusted Modelsa β (95% CI) (N=215) | Male Only Adjusted Modelsa β (95% CI) (N=206) | |
|---|---|---|---|---|---|
| DPHP† | 0.01 (−0.07, 0.08) | −0.01 (−0.09, 0.06) | 0.40 | −0.03 (−0.13, 0.08) | 0.03 (−0.09, 0.15) |
| DNBP+DIBP† | 0.04 (−0.06, 0.15) | 0.06 (−0.05, 0.16) | 0.62 | 0.01 (−0.15, 0.17) | 0.10 (−0.04, 0.25) |
| BDCIPP† | −0.03 (−0.08, 0.02) | −0.03 (−0.07, 0.02) | 0.48 | −0.00 (−0.07, 0.07) | −0.05 (−0.12, 0.03) |
| BCEP† | 0.00 (−0.03, 0.03) | 0.01 (−0.02, 0.04) | 0.79 | 0.01 (−0.03, 0.06) | −0.00 (−0.05, 0.04) |
| BBOEP† | 0.06 (−0.02, 0.13) | 0.04 (−0.03, 0.11) | 0.69 | 0.03 (−0.08, 0.14) | 0.07 (−0.03, 0.17) |
| BCIPP | 0.28 | ||||
| Non-detect | REF | REF | REF | REF | |
| Detect | 0.00 (−0.19, 0.20) | −0.02 (−0.22, 0.17) | 0.11 (−0.17, 0.40) | −0.15 (−0.42, 0.12) | |
| BMPP | 0.19 | ||||
| Non-detect | REF | REF | REF | REF | |
| Detect | 0.10 (−0.10, 0.30) | 0.06 (−0.13, 0.26) | 0.22 (−0.07, 0.52) | −0.05 (−0.33, 0.22) | |
| BEHP | 0.30 | ||||
| Non-detect | REF | REF | REF | REF | |
| Detect | −0.06 (−0.29, 0.16) | −0.09 (−0.32, 0.13) | −0.24 (−0.58, 0.10) | 0.02 (−0.29, 0.33) | |
| DPRP | 0.65 | ||||
| Non-detect | REF | REF | REF | REF | |
| Detect | 0.11 (−0.12, 0.34) | 0.10 (−0.13, 0.32) | 0.04 (−0.30, 0.38) | 0.16 (−0.17, 0.48) |
Model adjusted for recruitment site, maternal age, season of sample collection, gestational age at sample collection, race/ethnicity, pre-pregnancy BMI, income, education, infant birth order, maternal hypertensive disorders of pregnancy.
Beta estimate back transformed to a doubling in exposure
Note: OPE, Organophosphate Ester; DPHP, Diphenyl phosphate; DNBP+DIBP, Sum of Dibutyl phosphate and Di-isobutyl phosphate; BDCIPP, Bis(1,3-dichloro-2-propyl) phosphate; BCEP, Bis(2- chloroethyl) phosphate; BBOEP, Bis(butoxethyl) phosphate; BCIPP, Bis(1-chloro-2-propyl) phosphate; BMPP, Bis(2-methylphenyl) phosphate; BEHP, Bis(2-ethylhexyl) phosphate; DPRP, Dipropyl phosphate.