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. 2023 Apr 14;14:2122. doi: 10.1038/s41467-023-37807-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a tSNE plot of normal mammary gland ECs isolated from pooled (n = 20) mammary glands. b tSNE plot showing Dnmt1 expression amongst the different clusters. The arrowhead points to cluster 12. c Violin plots showing enrichment of Dnmt1 and Top2a in cluster 12. d tSNE plot showing Top2a expression in PyMT TECs. e Dnmt1 expression in blood versus mitotic TECs from the PyMT model. f tSNEs depicting gene set enrichment scores for E2F targets (found in the mitotic cluster) and IFN or TNF response (found mainly in the non-mitotic clusters). g Clustering for E0771 and PyMT TECs including annotated clusters and Top2a or Dnmt1 expression. The arrowhead points to the mitotic cluster. h Co-expression of Dnmt1 and Cxcl9 or Cxcl10 in mitotic versus the IFN-like cluster. i Bubble plots for candidate IFN response genes and mitotic genes depicted by vessel subtype.