Table 1.
Fibroblast activation and reprogramming mediated by HNSCC-derived EVs.
| Cancer type | EVs-secreted content | Stromal target cells | Mechanism | References |
|---|---|---|---|---|
| Head and neck squamous cell carcinoma | miR-192/215 | Human foetal lung fibroblasts (MRC-5cells) | Targeting regulating Caveolin-1 | [134] |
| Oral squamous cell carcinoma | LncRNA CAFs | Oral fibroblasts | Regulating IL-33 | [135] |
| Head and neck squamous cell carcinoma | TGFβ1 | Head and neck fibroblasts | Regulating Fibronectin | [43] |
| Nasopharyngeal carcinoma | LMP1 | Nasopharyngeal fibroblasts | NF-κB p65 signaling pathway | [103] |