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. 2023 Apr 13;13:6096. doi: 10.1038/s41598-023-33263-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Light-up experiment. (A) Sequences of oligonucleotides used in the light-up experiment with the G bases involved in the formation of G-quadruplexes in bold and the G-tracts numbered. The abbreviation ‘wt’ indicates the LTR oligonucleotide with a wild-type sequence capable of folding into G-quadruplex structures. ‘M4 + M5’ indicates the LTR oligonucleotide with two point mutations (highlighted in red) that is unable to form G-quadruplexes. ‘Scrambled’ is the labelling of the LTR oligonucleotide with the identical base composition as the wild-type oligonucleotide, but with a scrambled sequence. (B) Emission spectra of 12 after incubation with different oligonucleotides or the reaction buffer alone after excitation at 280 nm. The inset represents a fluorescent image of the wells with compound 12 and a given oligonucleotide after UV-light excitation taken with the Bio-Rad ChemiDoc imaging system.