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. 2023 Jan 7;42(5):1327–1338. doi: 10.1007/s10067-022-06491-7

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — CD8⁺ T cell counts in LSG tissues and its correlations with disease parameters. A–C Representative images of three groups of patients: control patients (n = 6, A), pSS patients who were salivary gland 0≤ FS <1 (n = 12, B), and pSS patients who were salivary gland FS ≥1 (n = 11, C). D Comparations between the three groups. E Correlations of CD8⁺ T cell counts with disease parameters in pSS patients. Spearman correlation coefficients (r) and p values are indicated. CD8⁺ T cell counts had significant positive correlations with IgG, RF, ANA, and IFN-γ and had a negative correlation with complement C3. Left scale bars = 200 μm, right scale bars = 50 μm. Horizontal lines represent median and interquartile range, *p < 0.05, ***p < 0.001. IFN-γ: pg/mL; IgG: mg/dL; ESR: mm/h; RF: IU/mL; C3: mg/dL; C4: mg/dL. ANA titres graded at 4 levels (1:320, 1:1000, 1:3200, and 1:10000)