Fig. 1.

Synthesis and characterization of control and cRGD-decorated CCPM. A The schematic representation exemplifies the synthetic process of cRGD-CCPM, including the polymer units self-assembly and crosslinking, followed by the decoration of the CCPM by cRGD peptide via click chemistry. B The physicochemical characterization of CCPM including nanoparticle size (nm), dispersitiy (PdI), lactic acid content (LA; indirect indicator of polymer content), and polymer concentration (PC) indicates decorated and non-decorated CCPM to display a similar size of 35–40 nm, a polydispersity index comprised between 0.15 and 0.34, and a similar polymer content of approximately 1 mg/ml of polymer