Fig. 7.

Quantitative comparison of the uptake of control and cRGD-decorated CCPM by α_νβ₃-integrin^high cell lines. A and B Quantification of the uptake of control and cRGD-decorated CCPM by 4T1 cells. C and D Quantification of the uptake of control and cRGD-decorated CCPM by HUVEC.⁺. Despite the elevated uptake of the cRGD-decorated CCPM in comparison to control CCPM by both cell lines, the uptake is not proportional to the decoration density. In other words, both 3.6 and 5 mol% decoration does not quantitatively improve the CCPM uptake in comparison to the 1 mol% cRGD decoration. This observation denotes that higher and higher decoration densities do not result in “inifinite” increases with respect to the formulation binding or uptake