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. 2023 Apr 13;14:2094. doi: 10.1038/s41467-023-37832-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Heatmap of miRNA differential expression analysis between samples. Red represents upregulated genes, green represents downregulated genes, and color depth represents log10^(COUNT+1) values. b Scatter plot of miRNA differential expression analysis between samples. Red dots indicate significantly upregulated miRNAs, and green dots indicate significantly downregulated miRNAs. c The expression of miR-126a-3p in the EVs was measured by qRT‒PCR. **p < 0.01 vs. EPC-EVs, ##p < 0.01 vs. CS-EPC-EVs (n = 5, biological replicates per group). d qRT‒PCR detection of miR-126a-3p expression in EPCs after silicate ion treatments. *p < 0.05 and **p < 0.01 vs. EPC-EVs (n = 5, biological replicates per group). e The expression of miR-126a-3p in HUVECs treated with different EVs under glucose and oxygen deprivation (n = 5, biological replicates per group) **p < 0.01 vs. OGD, ##p < 0.01 vs. CS-EPC-EVs. Data are presented as the mean ± standard. Two-tailed Student’s t-test was used to compare the differences between two groups. One-way ANOVA and post hoc Bonferroni tests were used to compare differences among more than two groups. Source data are provided as a Source Data file. Each experiment was repeated 3 times or more independently with similar results.