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. 2023 Apr 13;14:2094. doi: 10.1038/s41467-023-37832-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 9 — a The expression of hnRNPA2B1, Sphingomyelin Phosphodiesterase 3 (SMPD3), Syncrip, Y-box binding protein 1 (Ybx1), and Annexin A2 (ANXA2) in EPCs after culture with silicate ions (CS-EPCs) for 48 h. b Western blot analysis of hnRNPA2B1 and nSMase2 proteins in EPCs after culture with silicate ions for 48 h. *p < 0.05 vs. EPC. c The expression of hnRNPA2B1 and SMPD3 in CS-EPCs after knockdown with specific siRNA. d Protein analysis of hnRNPA2B1 and nSNase2 in CS-EPCs after knockdown with specific siRNA. e, f The expression of miR-126a-3p in EVs after knockdown of hnRNPA2B1 (e) and SMPD3 (f). g, h The expression of miR-126a-3p in EPCs after knockdown of hnRNPA2B1 (g) and SMPD3 (h). #p < 0.05 vs. the other two groups. Data are presented as the mean ± standard. Two-tailed Student’s t-test was used to compare the differences between two groups. One-way ANOVA and post hoc Bonferroni tests were used to compare differences among more than two groups. Source data are provided as a Source Data file. Each experiment was repeated 3 times or more independently with similar results.