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. 2023 Apr 13;14:2102. doi: 10.1038/s41467-023-37179-4

Fig. 6. MOMA predicts MSI status in colorectal cancer patients.

Fig. 6

A Our MSI prediction model achieves an area under the receiver operating characteristic curve (AUC) of 0.88 in the TCGA held-out test set. B Our MSI prediction model is further validated in the Nurses’ Health Study and Health Professionals Follow-up Study cohorts (AUC = 0.76). C Attention visualization of a pathology image with non-MSI-high cancer. Informative regions of cancer-associated stroma, cancer cells, and mucus in this prediction task are automatically highlighted by our trained machine learning model. D Attention visualization of a pathology image with MSI-high cancer. Regions with adenocarcinoma cells and their adjacent stroma receive high attention. STR cancer-associated stroma, MUC mucus, TUM colorectal adenocarcinoma epithelium.