Table 1.
Sensitivity and specificity of investigated oral fluid screening tests compared to laboratory reference tests of THC in blood or serum at positivity thresholds ranging from 0 to 5 ng/mL THC, as reported by 2 experimental studies of roadside tests for cannabis use.
| Screening Test (positivity threshold, ng/mL THC) | Study (sample) | Laboratory Reference Test (n tests; n reference test positives) | Sensitivity and specificity (% [95% CI]) at varying positivity thresholds (ng/mL THC) |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 0–0.5 |
1.0 |
2.0 |
5.0 |
|||||||
| SENS | SPEC | SENS | SPEC | SENS | SPEC | SENS | SPEC | |||
| Alere DDS | ||||||||||
| Alere DDS 2 Mobile Test System (25) | Newmeyer 2017 (adult occasional and frequent cannabis users) | LC-MS/MS in blood (134; 1.0: 78, 2.0: 41, 5.0: 21) | - | – | 43.6 (33.1–54.6) | 82.1 (70.2–90.0) | 65.9 (50.6–78.4) | 81.7 (72.7–88.3) | 85.7 (65.4–95.0) | 77.0 (68.4–83.8) |
| Draeger DrugTest | ||||||||||
| DrugTest 5000 (5) | Newmeyer 2017 (adult occasional and frequent cannabis users) | LC-MS/MS in blood (103; 1.0: 72, 2.0: 53, 5.0: 19) | – | – | 34.7 (24.8–46.2) | 87.1 (71.2–94.9) | 43.4 (31.0–56.7) | 88.0 (76.2–94.4) | 73.7 (51.2–88.2) | 82.1 (72.6–88.9) |
| Securetec DrugWipe | ||||||||||
| DrugWipe 5S (15) | Wille 2015 (adult regular cannabis users) | GC-MS in serum (72; 1.0: 42, 5.0: 26) | – | – | 50.0 (35.5–64.5) | 90.0 (74.4–96.5) | – | – | 80.8 (62.1–91.5) | 93.5 (82.5–97.8) |
CI = confidence interval; DDS = Drug Detection System; GC-MS = gas chromatography mass spectrometry; LC-MS/MS = liquid chromatography tandem mass spectrometry; THC = delta-9-tetrahydrocannabinol.
Comparative studies are demarcated in bold.