TABLE 1.
Matrix of pairwise comparisons on total blood loss (L) in intra‐articular administration (shown as mean difference and 95% confidence intervals)
| 0.5 g TXA IA | 1.0 g TXA IA | 1.5 g TXA IA | 2.0 g TXA IA | 3.0 g TXA IA | 5.0 g EACA IA | Placebo | |
|---|---|---|---|---|---|---|---|
| 0.5 g TXA IA | 1 | −0.119 (−0.263, 0.023) | −0.13 (−0.321, 0.065) | −0.237 (−0.394, −0.087) | −0.164 (−0.306, −0.021) | −0.016 (−0.192, 0.17) | 0.193 (0.055, 0.335) |
| 1.0 g TXA IA | 0.119 (−0.023, 0.263) | 1 | −0.011 (−0.166, 0.147) | −0.119 (−0.243, 0.003) | −0.045 (−0.151, 0.064) | 0.103 (−0.03, 0.248) | 0.311 (0.238, 0.391) |
| 1.5 g TXA IA | 0.13 (−0.065, 0.321) | 0.011 (−0.147, 0.166) | 1 | −0.108 (−0.285, 0.065) | −0.034 (−0.185, 0.117) | 0.114 (−0.064, 0.299) | 0.322 (0.183, 0.464) |
| 2.0 g TXA IA | 0.237 (0.087, 0.394) | 0.119 (−0.003, 0.243) | 0.108 (−0.065, 0.285) | 1 | 0.074 (−0.05, 0.203) | 0.222 (0.068, 0.389) | 0.431 (0.322, 0.544) |
| 3.0 g TXA IA | 0.164 (0.021, 0.306) | 0.045 (−0.064, 0.151) | 0.034 (−0.117, 0.185) | −0.074 (−0.203, 0.05) | 1 | 0.148 (0.005, 0.3) | 0.356 (0.266, 0.449) |
| 5.0 g EACA IA | 0.016 (−0.17, 0.192) | −0.103 (−0.248, 0.03) | −0.114 (−0.299, 0.064) | −0.222 (−0.389, −0.068) | −0.148 (−0.3, −0.005) | 1 | 0.208 (0.09, 0.321) |
| Placebo | −0.193 (−0.335, −0.055) | −0.311 (−0.391, −0.238) | −0.322 (−0.464, −0.183) | −0.431 (−0.544, −0.322) | −0.356 (−0.449, −0.266) | −0.208 (−0.321, −0.09) | 1 |
Note: Bold results mean statistically significance.
Abbreviations: IA, intra‐articular; TXA, tranexamic acid; EACA, aminocaproic acid.