TABLE 4.
Matrix of pairwise comparisons on HB drop (g/dL) in intra‐articular administration (shown as mean difference and 95% confidence intervals)
| 0.5 g TXA IA | 1.0 g TXA IA | 1.5 g TXA IA | 2.0 g TXA IA | 3.0 g TXA IA | 5.0 g EACA IA | Placebo | |
|---|---|---|---|---|---|---|---|
| 0.5 g TXA IA | 1 | −0.13 (−0.55, 0.31) | −0.19 (−0.76, 0.38) | −0.11 (−0.58, 0.38) | −0.06 (−0.54, 0.45) | 0.47 (−0.01, 0.98) | 0.84 (0.48, 1.2) |
| 1.0 g TXA IA | 0.13 (−0.31, 0.55) | 1 | −0.06 (−0.58, 0.45) | 0.02 (−0.34, 0.38) | 0.08 (−0.3, 0.46) | 0.61 (0.18, 1.03) | 0.97 (0.72, 1.21) |
| 1.5 g TXA IA | 0.19 (−0.38, 0.76) | 0.06 (−0.45, 0.58) | 1 | 0.08 (−0.47, 0.64) | 0.14 (−0.43, 0.71) | 0.67 (0.1, 1.24) | 1.03 (0.58, 1.48) |
| 2.0 g TXA IA | 0.11 (−0.38, 0.58) | −0.02 (−0.38, 0.34) | −0.08 (−0.64, 0.47) | 1 | 0.06 (−0.35, 0.45) | 0.59 (0.11, 1.06) | 0.95 (0.62, 1.27) |
| 3.0 g TXA IA | 0.06 (−0.45, 0.54) | −0.08 (−0.46, 0.3) | −0.14 (−0.71, 0.43) | −0.06 (−0.45, 0.35) | 1 | 0.53 (0.03, 1.03) | 0.89 (0.54, 1.24) |
| 5.0 g EACA IA | −0.47 (−0.98, 0.01) | −0.61 (−1.03, −0.18) | −0.67 (−1.24, −0.1) | −0.59 (−1.06, −0.11) | −0.53 (−1.03, −0.03) | 1 | 0.36 (0.01, 0.71) |
| Placebo | −0.84 (−1.2, −0.48) | −0.97 (−1.21, −0.72) | −1.03 (−1.48, −0.58) | −0.95 (−1.27, −0.62) | −0.89 (−1.24, −0.54) | −0.36 (−0.71, −0.01) | 1 |
Note: Bold results mean statistically significance.
Abbreviations: IA, intra‐articular; TXA, tranexamic acid; EACA, aminocaproic acid.