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. 2023 Mar 31;15:1148957. doi: 10.3389/fnsyn.2023.1148957

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Copyright © 2023 Uzay and Kavalali.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overview of the synaptic vesicle release. (A) Synaptic vesicles are docked to the presynaptic terminal, followed by priming and fusion that is mediated by the components of the synaptic release machinery. (B) Graphical depiction of synaptic vesicle release induced by the arrival of an action potential to the presynaptic terminal, preceded by priming of the docked synaptic vesicles. Cplx, complexin; Syt1, synaptotagmin-1; Syb2, synaptobrevin-2. (C) Graphical depiction representing different modes of synaptic vesicle release and their representative electrophysiological traces, that comprise evoked (synchronous and asynchronous) and spontaneous release.