Table 3.
Studies with functional and biochemical changes induced by consumption of hydrolyzed collagen.
| Collagen | Design | Population (n) | Period | Dose/day | Result | Reference |
|---|---|---|---|---|---|---|
| HC | D-RM | Young men 19–29 years (24) | 1 week | 20 g | ↓pain; ↑ muscle recovery (48 h after exercise); ↔β-CTX; ↔P1NP; ↔bone collagen inflammation and synthesis | [62] |
| BioCP | D-RM | Young athletes 18–30 years with knee discomfort during sport, both gender (139) | 12 weeks | 5 g | ↓pain related to physical activity; ↔ pain at rest; ↔mobility; ↓ other medication options after BCP treatment | [63] |
| UC-II | D-RM | Adults 40–75 years with OA, both gender (186) | 25 weeks + 5 days | 0.4 g | ↓WOMAC; ↓pain; ↓stiffness; ↑mobility; ↓VAS score; ↓ LFI Score,↔ serum markers and knee flexibility | [64] |
| HC (Biocell Collagen®) | D-RCT | Adults 40–70 years with OA, both gender (68) | 10 weeks | 2 g | ↓pain (VAS score); ↓WOMAC; ↑PA | [65] |
| Type II | D-RCT | Adults 18–65 years with RA, both gender (454) | 24 weeks | 0.1 mg | ↓pain; ↓joint stiffness; ↓ number of tender and swollen joints; ↓HAQ | [66] |
| SCP | D-RCT | Athletes 26.9 ± 9.1 years with ankle instability, both gender (50) | 24 weeks | 5 g | ↑ subjective ankle stability; ↓ joint injuries over time; ↔ankle stiffness; ↔feeding behavior | [67] |
| HC | D-RM | Caucasian adults 50 years or over with joint pain, both gender (144) | 24 weeks | 1.2 g | ↔pain; ↑clinical response (VAS score) | [68] |
| PCP and BCP | D-RCT | Adults and middle-aged individuals 30–65 years diagnosed with knee OA, both gender (30) | 13 weeks | 5 g | ↓ WOMAC, VAS and QOL | [69] |
| CP (Peptan B2000®) | D-RCT | Middle-aged to elderly individuals 50–75 years physically active, both gender (167) | 12 weeks | 10 g | ↔ knee joint pain and knee function | [70] |
| HC | D-RCT | Young adults 20.1 ± 1.47 years, physically active, both gender (72) | 24 weeks | 10 g | ↓ joint pain; ↓ use of alternative therapies | [71] |
| HC (Fortigel®) | D-RCT | Middle-aged to elderly individuals 49 years or older with mild to moderate severity knee OA (29) | 48 weeks | 10 g | ↑dGEMRIC score in medial and lateral tibial cartilage regions | [72] |
| HC (Colnatur®) | RCT | Middle-aged to elderly individuals 48–70 years with light symptomatology OA (207) | 6 months | 10 g | ↓ VAS for knee pain; ↓ WOMAC pain score | [73] |