Table 1.

Concept table.

PICOS element	Inclusion criteria	Exclusion criteria
Problem	Humans Animals	In vitro experiments
Intervention	Hyaluronic acid fillers	Nonhyaluronic acid fillers Other injectables
Comparison/control	-	-
Outcome	Vascular (arterial and venous) events and complications including thrombus formation, embolization, occlusion, compression, and vasospasm	Plastic surgery intervention Infection Swelling Nodule formation
Study design	English language texts Case Studies Randomised controlled trials Review articles Meta-analysis Studies dated 2010-2020	NonEnglish language texts Studies dates prior to 2010