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. 2023 Mar 28;20:100620. doi: 10.1016/j.mtbio.2023.100620

Fig. 1.

Fig. 1

Characterization of collagen IV-targeted lipopolyplexes encapsulating the shRNA plasmid. Average hydrodynamic diameter and polydispersity indices (A-a) and Zeta potential (A-b) of collagen IV-targeted lipopolyplexes (Cp-LPP/shCtr) and non-targeted lipopolyplexes (S-LPP/shCtr); results are reported as mean ​± ​S.D. for three individual measurements. Cytotoxicity assay evaluated as adenylate kinase (AK) release in the culture medium at 48 ​h after transfection of oVIC seeded on 2D support (B-a) and in 3D aortic root-derived hydrogel (B-b) performed on the 5th and 12th day; data are presented as mean ​± ​S.D. of four experiments done in duplicates.