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. 2023 Mar 31;14:1142374. doi: 10.3389/fphar.2023.1142374

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Copyright © 2023 Li, Chen, Ma, Du and Han.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Biodistribution of drug-loaded nanoparticles in tumor-bearing mice. (A) In vivo fluorescent imaging of tumor-bearing mice after intravenous injection of NP/R848/siCD47/DiD at different time points. (B) Ex vivo fluorescent imaging of the tumor and other organs. (C,D) Percentage of DiD⁺ cells in DCs and CD45⁻ tumor cells isolated from mice injected with PBS, NP/R848/siCD47, or NP/DiD. Data were presented as mean ± SEM (n = 3). ****, p < 0.0001 by multiple one-way ANOVA.