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. 2023 Mar 31;14:1148988. doi: 10.3389/fimmu.2023.1148988

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Copyright © 2023 Sanz, Mann, Ryan, Bosque, Pennington, Hackstein and Soriano-Sarabia

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transcription factors associated with upregulated genes within Vδ1 and Vδ2 T cell subsets. (A) The Predicting associated transcription factors from annotated affinities (PASTAA) software revealed a list of four transcription factors (TFs) associated with Vδ1 T cells, five TFs common to both subpopulations, and 42 associated with Vδ2 T cells. (B) Top TFs associated with Vδ1 and Vδ2 T cells, are shown. Upon stimulation with ionomycin (C) NFAT (D) AhR and (E) CD69 or α-CD3 monoclonal antibody (F) NFAT (G) AhR and (H) CD69 expression were analyzed in Vδ1 and Vδ2 T cells after 3 and 24 hours of exposure in the presence or absence of inhibitors of NFAT (cyclosporine A, CsA) or AhR (CH223191). Wilcoxon Rank-Sum test were used to compare the data. Normalized mean fluorescence intensity (MFI) and frequency of CD69 expression to the untreated or DMSO controls are presented.