. 2023 Mar 31;10:1089733. doi: 10.3389/fvets.2023.1089733

Table 2.

Effects of melatonin on the cardiological and nephrological function parameters among all groups (mean ± SEM).

Item	Urea (mg/dl)	Creatinine (mg/dl)	CK-MB (U/L)	TNO (μM/ml)	Endothelin-1 (pg/ml)	Myogb (ng/ml)	H-FABP (ng/ml)	TAC (mmol/L)	TOC (mmol/L)
Control	47.56 ± 3.82^a	0.6 ± 0.04^a	14.39 ± 0.13^a	54.73 ± 0.22^a	0.38 ± 0.003^a	32.51 ± 0.34^a	15.18 ± 0.06^a	1.44 ± 0.01^a	0.38 ± 0.00^a
DM	105.72 ± 6.34^b	0.71 ± 0.02^b	27.09 ± 0.22^b	37.09 ± 0.48^b	0.74 ± 0.011^b	70.41 ± 0.46^b	32.26 ± 0.25^b	0.78 ± 0.01^b	0.82 ± 0.00^b
MLT	50.09 ± 2.01^a	0.69 ± 0.03^bc	14.16 ± 0.07^a	54.48 ± 0.25^a	0.38 ± 0.003^a	32.36 ± 0.35^a	15.11 ± 0.08^a	1.44 ± 0.00^a	0.38 ± 0.00^a
DM + MLT	112.76 ± 7.38^b	0.73 ± 0.01^b	22.39 ± 0.30^c	42.81 ± 0.57^c	0.54 ± 0.015^c	51.95 ± 0.32^c	24.09 ± 0.18^c	0.94 ± 0.00^c	0.60 ± 0.01^c
DM + INS	89.18 ± 7.38^c	0.64 ± 0.03^ac	19.54 ± 0.18^d	48.89 ± 0.22^d	0.43 ± 0.013^d	44.80 ± 0.34^d	20.13 ± 0.33^d	1.15 ± 0.03^d	0.52 ± 0.00^d

^a−d

Means in the same column with different superscripts are significant at a P-value of < 0.05.

CK-MB, creatine kinase-MB; TNO, total nitric oxide; Myogb, myoglobin; H-FABP, cardiac fatty acid-binding protein; TAC, total antioxidative capacity; TOC, total oxidative capacity.