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. 2023 Mar 31;10:1156062. doi: 10.3389/fmolb.2023.1156062

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Copyright © 2023 Shi, Xiong, Yan, Du, Liu and Shi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DHA enhances oxidative stress in cervical cancer cells. Levels of (A) MDA, (B) SOD and (C) CAT in HeLa and SiHa cells treated with 0, 40 and 80 μM DHA for 24 h. (D) The images and (E) fluorescence intensity of intracellular LPO stained by BODIPY^™ 581/591 C11 (100×; Scale bar: 200 µm). C11-BODIPY represents the level of staining with the probe (unoxidized), while oxC11-BODIPY (oxidized) represents the level of LPO. DHA: dihydroartemisinin; Rel. relative; MDA: malondialdehyde; SOD: superoxide dismutase; CAT: catalase; LPO: liquid peroxidation. (*, p < 0.05; **, p < 0.01; ***, p < 0.001 compared with control group; ns: no significance.).