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. 2023 Mar 31;10:1156062. doi: 10.3389/fmolb.2023.1156062

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Copyright © 2023 Shi, Xiong, Yan, Du, Liu and Shi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DHA triggers cervical cancer cells ferroptosis. Effects on (A) cell viability and (B) MDA level of HeLa and SiHa cells after 24 h of DHA treatment with or without Z-VAD-FMK, Fer-1 or DFO. (C) The transcriptional levels of ACSL4, GPX4 and xCT after DHA treatment. (D) The protein expressions of ACSL4, GPX4 and xCT after DHA treatment, compared with β-actin. Levels of (E) GSH and (F) GPx in HeLa and SiHa cells treated with 0, 40 and 80 μM DHA for 24 h. Rel. relative; DHA: dihydroartemisinin; MDA: malondialdehyde; Fer-1: ferrostatin-1; DFO: deferoxamine; ACSL4: acyl-CoA synthetase long-chain family member 4; GPX4: glutathione peroxidase 4; xCT: cystine-glutamate antiporter; GSH: glutathione; GPx: glutathione peroxidase. (*, p < 0.05; **, p < 0.01; ***, p < 0.001 compared with control group; #, p < 0.05; ##, p < 0.01; ###, p < 0.001 compared with DHA group; ns: no significance.).