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. 2023 Mar 31;10:1156062. doi: 10.3389/fmolb.2023.1156062

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Copyright © 2023 Shi, Xiong, Yan, Du, Liu and Shi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DHA sensitizes cervical cancer to DOX-induced cell death. (A, B) Heatmaps of drug combination responses. Synergy score >10 is considered synergistic, between −10 and +10 is considered additive, <−10 is considered antagonistic. The gradation of the red regions indicates the intensity of synergism. The white rectangle indicates the concentrations encompassing the region of highest synergy. Effects on the levels of (C) MDA and (D) GSH in HeLa and SiHa cells after 24 h of treatment with DOX with or without DHA. (E) Effects of Fer-1 on cell viability of HeLa and SiHa cells treated with DOX and DHA. Rel. relative; DHA: dihydroartemisinin; DOX: doxorubicin; MDA: malondialdehyde; GSH: glutathione; Fer-1: ferrostatin-1. (*, p < 0.05; **, p < 0.01; ***, p < 0.001 compared with control group; #, p < 0.05; ##, p < 0.01; ###, p < 0.001 compared with DOX group).