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. 2023 Mar 31;10:1156062. doi: 10.3389/fmolb.2023.1156062

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Copyright © 2023 Shi, Xiong, Yan, Du, Liu and Shi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic depicting DHA-induced ferroptosis in cervical cancer cells. DHA: dihydroartemisinin; GPX4: glutathione peroxidase 4; GSH: glutathione; GSSG: oxidized glutathione; CoA: coenzyme A; PUFA: polyunsaturated fatty acids; ACSL4: acyl-CoA synthetase long-chain family member 4; PLO: liquid peroxidation; Fe³⁺, ferric iron; Fe²⁺, ferrous iron; TfR1: transferrin receptor 1; Steap3: six transmembrane epithelial antigen of the prostate 3; FT: ferritin; NCOA4: nuclear receptor coactivator 4; LIP: labile iron pool; FPN1: Ferroportin1; HO-1: heme oxygenase-1.