Table 4.
Sensitive analysis of T1DM on outcomes.
| Outcomes | F statistics | Heterogeneity | Pleiotropy (MR-Egger) | Outliers (MR-PRESSO) |
||
|---|---|---|---|---|---|---|
| MR-Egger | IVW | Intercept | p-value | |||
| Sepsis | 22.27958 | p=0.0691 | p=0.0833 | 0.002 | 0.7546 | NO |
| ALRIs | 22.79959 | p=0.6079 | p=0.6557 | 0.0008 | 0.8921 | NO |
| IIs | 22.80604 | p=0.4049 | p=0.4447 | -0.0041 | 0.6633 | NO |
| GUTIs in pregnancy | 22.87157 | p=0.5019 | p=0.5144 | -0.0134 | 0.3923 | NO |
| SSTIs | 22.79959 | p=0.0299 | p=0.0336 | 0.005 | 0.5048 | NO |
| UTIs | 30.5624 | p=0.2689 | p=0.3174 | -2.882E-6 | p =0.9769 | NO |
T1DM, Type 1 diabetes mellitus; IVW, inverse-variance weighted; MR-PRESSO, Mendelian randomization pleiotropy residual sum and outlier; ALRIs, acute lower respiratory infections; IIs, intestinal infections; GUTIs, infections of genitourinary tract; SSTIs, Infections of the skin and subcutaneous tissue; UTIs, urinary tract infections. Statistical significance was set at p< 0.05.