Table 3.
Descriptive WMH data for the SLE group and the SLICC A, SLICC B and NPACR groups. The differences in rCBF, rCBV, rMTT and K2 are presented as the mean increase in percent in WMHs relative to NAWM. Values shown in bold were statistically significant (p < 0.05).
| SLE | SLICC A |
SLICC B |
NPACR |
||||
|---|---|---|---|---|---|---|---|
| NPSLE | non-NPSLE | NPSLE | non-NPSLE | NPSLE | non-NPSLE | ||
| Patients with WMHs, n (%)1 | 31 (48 %) | 9 (69 %) | 22 (43 %) | 12 (63 %) | 19 (42 %) | 16 (42 %) | 15 (58 %) |
| Age [years], median (range) | 41 (20–52) | 41 (28–48) | 41 (20–52) | 40.5 (23–48) | 43 (20–52) | 41 (23–48) | 42 (20–52) |
| WMH burden [n/patient], median (range)2 | 2 (1–25) | 2 (1–20) | 2 (1–25) | 2.5 (1–20) | 2 (1–25) | 2 (1–20) | 2 (1–25) |
| WMH size [ml/WMH], median (range)2 | 0.074 (0.044–0.222) | 0.074 (0.052–0.222) | 0.081 (0.044–0.155) | 0.073 (0.052–0.222) | 0.091 (0.044–0.155) | 0.073 (0.044–0.222) | 0.096 (0.044–0.155) |
| WMH volume [ml/patient], median (range)2 | 0.192 (0.044–3.062) | 0.163 (0.074–1.716) | 0.222 (0.044–3.062) | 0.192 (0.059–1.716) | 0.192 (0.044–3.062) | 0.178 (0.044–1.716) | 0.251 (0.044–3.062) |
| WMH vs NAWM3 | |||||||
| rCBF, % (p value) | 39.1 % (<0.001) | 48.2 % (0.021) | 35.3 % (<0.001) | 39.6 % (0.03) | 38.8 % (<0.001) | 28.5 % (0.07) | 50.6 % (<0.001) |
| rCBV, % (p value) | 69.0 % (<0.001) | 56.7 % (0.052) | 74.5 % (<0.001) | 54.2 % (0.053) | 78.1 % (0.001) | 47.8 % (0.04) | 90.5 % (<0.001) |
| rMTT, % (p value) | 21.4 % (0.005) | 5.6 % (0.6) | 28.2 % (0.006) | 11.6 % (0.4) | 27.6 % (0.008) | 15.5 % (0.07) | 27.2 % (0.02) |
| K2, % (p value) | 231.4% (<0.001) | 119.1 % (0.2) | 273.7 % (<0.001) | 87.0 % (0.2) | 358.1 % (<0.001) | 126.7 % (0.1) | 385 % (<0.001) |
SLE = Systemic lupus erythematosus, NPSLE = Neuropsychiatric SLE, SLICC = Systemic Lupus International Collaborating Clinics, NPACR = American College of Rheumatology case definitions for NPSLE, WMH(s) = White matter hyperintensity(s), NAWM = Normal appearing white matter, rCBF = Relative cerebral blood flow, rCBV = Relative cerebral blood volume, rMTT = Relative mean transit time, K2 = Blood-brain barrier leakage parameter.
The number and percentage of patients in the respective group (SLE, SLICC A, SLICC B, NPACR) that presented with measurable WMHs.
Based on the regions of interest which were placed in the perfusion weighted images (defined as 3 pixels or volume ≥ 0.044 ml).
The mean increase in percent in the WMHs relative to NAWM, calculated as ((WMH/NAWM) − 1) × 100.