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. 2023 Mar 31;14:1125948. doi: 10.3389/fimmu.2023.1125948

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Copyright © 2023 Al Aameri, Alanisi, Oluwatosin, Al Sallami, Sheth, Alberts, Patel, Rybak and Ramkumar

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Scheme show the hypothesis of cisplatin effect on cochlea. (A) Cisplatin administration up regulates CXCL1 levels, especially in SG, and recruit immune cells migration to cochlea through spiral ligament and stria vascularis. Pretreatment with trans-tympanic SB225002 (B) followed by cisplatin administration down regulates CXCL1 expression in SG neurons, SV and SL and inhibit immune cell migration to cochlea.