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. 2023 Mar 31;14:1112865. doi: 10.3389/fneur.2023.1112865

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Copyright © 2023 Jones, Donahue, Davis, Pruthi, Waddle, Custer, Patel, DeBaun, Kassim, Rodeghier and Jordan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Plots of gray matter volume and white matter volume with hemoglobin, gray matter CBF, or log-transformed infarct (lesion) burden, displaying the multivariable regression model-predicted association between each covariate and volume, controlling for age, sex, and intracranial volume, with 95% confidence intervals (gray line and shaded area). Models include healthy controls and participants with SCD (A,B) or participants with SCD and silent cerebral infarcts only (C). Overlaid on the model predictions are the raw data.