Table 1.
Study demographics.
| Control (n = 49) | SCD (n = 88) | p a | |
|---|---|---|---|
| Black race, n (percent) | 49 (100.0%) | 86 (97.73%) | 0.54c |
| Male sex, n (percent) | 21 (42.86%) | 43 (48.86%) | 0.25 |
| Hemoglobin genotype | 49 HbAA 100%) | 80 HbSS (91%) 8 HbSB0 (9%) | n/a |
| Age at MRI, years, median (IQR) | 23.75 (12.83) | 18.06 (15.42) | 0.26d |
| SCI present, n (percent) | n/a | 31 (35.23%) | n/a |
| SCI counte, median (IQR) | n/a | 4 (5) | n/a |
| Total SCI burdene, mL, median (IQR) | n/a | 0.14 (0.33) | n/a |
| Gray matter volume, mean (SD) | 619.40 (74.16) | 626.21 (67.99) | 0.588 |
| White matter volume, mean (SD) | 441.31 (55.17) | 435.62 (62.52) | 0.595 |
| GM CBF, ml/100 g/min, mean (SD) | 50.64 (8.9) | 82.47 (17.92) | <0.001 |
| WM CBF, ml/100 g/min, mean (SD) | 24.99 (4.16) | 40.49 (10.81) | <0.001 |
| Regular blood transfusions, n (percent) | n/a | 0 (0.0%) | n/a |
| CaO2, mL/dL, mean (SD) | 17.38 (2.12) | 11.63 (1.85) | <0.001 |
| SaO2, percent, median (IQR) | 98.0 (2.0) | 96.0 (3.26) | <0.001d |
| Hemoglobin, g/dL, mean (SD) | 13.28 (1.57) | 9.04 (1.37) | <0.001 |
| Hemoglobin S fraction, percent, median (IQR) | n/a | 0.77 (0.16) | n/a |
| Intracranial stenosis > 70%, n, (percent) | 0 (0.0%) | 0 (0.0%) | n/a |
| Hydroxyurea therapy, n (percent) | n/a | 79 (89.77%) | n/a |
| Type 1 diabetes mellitusb, n (percent) | 3 (6.12%) | 2 (2.27%) | 0.35c |
| Hypercholesterolemiab, n (percent) | 0 (0.0%) | 0 (0.0%) | n/a |
| Coronary artery diseaseb, n (percent) | 0 (0.0%) | 0 (0.0%) | n/a |
| Smoking currently, n (percent) | 2 (4.08%) | 8 (9.09%) | 0.49c |
| Body mass index, kg/m2, mean (SD) | 23.29 (8.23) | 21.14 (4.54) | 0.054 |
aChi-square test for categorical variables and t-test for continuous variables, unless otherwise noted. bDocumented in medical records and/or self-reported by study participant. cFisher exact test used if one cell < 5. dMann–Whitney U test used for non-normally distributed data: interquartile range (IQR) reported instead of SD and median reported instead of mean. eStatistics for lesion count and volume calculated using only participants with 1 or more SCI. CaO2, arterial oxygen content; SaO2, blood oxygen saturation; SCD, sickle cell disease; SCI, silent cerebral infarct; HbSB0, hemoglobin S β0 thalassemia.