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. 2023 Mar 31;11:1146881. doi: 10.3389/fbioe.2023.1146881

TABLE 6.

ALA enrichment methods.

Advantages Disadvantages
Solvent Extraction Simple operation Low purity
Silver Ion Complexation Good separation effect. Expensive. Heavy metal pollution.
High product purity
Molecular Distillation No foreign substances’ introduction. Need high vacuum.
Temperature is far below the boiling point. High energy consumption.
Short heating time. Low purity of the product.
Fit for continuous production. Not ideal for the separation of fatty acids with similar molecular weights.
Low-temperature Crystallization Cheap equipment, easy to operate, and can effectively protect active ingredients A large amount of organic solvent needs to be recovered, and the separation efficiency is not high.
Urea Complexation Simple process, low cost, and the active ingredients protective. Difficulty separating fatty acids with similar degrees of unsaturation.