Figure 3. Reduction in number of Olfr160-expressing olfactory sensory neurons in mice following consumption of moderately high-fat diet.
A, Representative coronal tissue section of an olfactory epithelium (OE) at 50X (left), 100X (center), and 400X (right) magnification acquired from a M72tauLacZ male mouse maintained on a control diet ad libitum (CF adlib). The indigo cells are Olfr160-expressing olfactory sensory neurons (OSNs). oe = olfactory epithelium, osn = olfactory sensory neuron. B, Representative images of an OE following one of the four dietary treatments in male (top) and female (bottom) mice. C, Bar graph of the number of Olfr160-expressing OSNs vs dietary treatment in males (left) and females (right). Notations and statistical analyses as in Fig. 2. Males = 8, 8, 8, 9 | Females = 6, 7, 8, 8.