Figure 5. Male, and not female mice, increase adiposity when dietary fat is consumed ad libitum rather than isocaloric pair-fed. Both sexes demonstrate an impaired glucose clearance when dietary fat is consumed ad libitum, and an intermediate impairment when consumed isocalorically.
A, Bar graph of fat and lean tissue mass vs dietary treatment in male (left) and female (right) M72tauLacZ mice. B, Bar graph of excised fat pad weight vs dietary treatment; male (left), female (right). Epi = epididymal, Retro = retroperitoneal, Mes = mesenteric, Sub = subcutaneous, Brown = intrascapular brown, Endo = endometrial. C, Line graph of the plasma glucose concentration during the IPGTT; Inset: Bar graph of the integrated area under the curve (iAUC). Notations and statistical analyses as in Fig. 2. Males = 8, 8, 9, 9 | Females = 9, 10, 9, 9.