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. 2023 Feb 7;83(8):1203–1213. doi: 10.1158/0008-5472.CAN-22-2236

Figure 1.

Figure 1. The methylome of brain metastases from prostate cancer is largely inherited from primary tumors and is driven by genomic background. A, PCA using the 1% most variably methylated CpG sites from the Illumina EPIC array (8,038 sites). B, Spearman correlation between eigenvectors of PCs 1–10, with sample type (i.e., primary tumor vs. metastasis), patient, and mutational status (*, P < 0.05; **, P < 0.01; ***, P < 0.001). C, Euclidean distance between primary samples and normal prostate samples and between metastatic and normal samples. D, Euclidean distance between primary samples within each patient, metastatic samples within each patient, and between primary and metastatic samples within each patient. E, As in D, but comparison done between patients. PCBM primary n = 57, PCBM metastasis n = 95, normal prostate n = 2.

The methylome of brain metastases from prostate cancer is largely inherited from primary tumors and is driven by genomic background. A, PCA using the 1% most variably methylated CpG sites from the Illumina EPIC array (8,038 sites). B, Spearman correlation between eigenvectors of PCs 1–10, with sample type (i.e., primary tumor vs. metastasis), patient, and mutational status. *, P < 0.05; **, P < 0.01; ***, P < 0.001. C, Euclidean distance between primary samples and normal prostate samples and between metastatic and normal samples. D, Euclidean distance between primary samples within each patient, metastatic samples within each patient, and between primary and metastatic samples within each patient. E, As in D, but comparison done between patients. PCBM primary, n = 57; PCBM metastasis, n = 95; normal prostate, n = 2.