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Effect of DOI (0.5 mg/kg) on startle amplitude (a) and %PPI (b) in male 129S6/SvEv mice. Experimental conditions included a 40-ms pulse at 120 dB; 20 ms prepulses at 72, 75, and 81 dB; an interstimulus interval of 80 ms; and background noise set to 69 dB (n = 9–10 mice per group). Two-way ANOVA followed by Sidak’s multiple comparison test. *p < 0.05, **p < 0.01, n.s., not significant
