Effect of M100,907 (1.0 mg/kg) and DOI (0.5 mg/kg) on startle amplitude (a) and %PPI (b) in male 129S6/SvEv mice. Experimental conditions included a 20-ms pulse 120 dB; 20 ms prepulses at 73, 77, and 85 dB; an interstimulus interval of 80 ms; and background noise set to 69 dB (n = 9–10 mice per group). Two-way ANOVA followed by Sidak’s multiple comparison test. *p < 0.05, **p < 0.01, n.s., not significant