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The allosteric effect of the 5-HT2AR agonist DOI on the affinity of LY379268 displacing the mGluR2/3 antagonist [3H]LY341495 is increased in frontal cortex samples of schizophrenia subjects. This suggests that the functional crosstalk between 5-HT2AR and mGluR2 as a GPCR heterocomplex may be involved in the altered cortical processes in schizophrenia patients.
