CKRT achieves superior volume control than intermittent HD in patients with critical illness. (A) Fluid accumulation over time in patients on CKRT and on intermittent HD. Percentage of fluid accumulation was calculated as fluid balance (fluid intake in liters minus total output in liters) divided by baseline body weight (in kilograms). Data from the Program to Improve Care in Acute Renal Disease (PICARD) study.18 (B) Twenty-four–hour total fluid balance (I/Os, in milliliters) during the first 3 days of KRT in patients on intermittent HD and CVVHD therapy. Shown are median values with interquartile range (box borders) and extreme values (whiskers). CKRT, continuous KRT; CVVHD, continuous venovenous hemodialysis; HD, hemodialysis. (A) Reprinted from ref. 18, with permission. (B) Reprinted from ref. 17, with permission.