Table 3.
One-way sensitivity analysis
| Base Case Analysis: Using Early WES versus Late WES Model Saves 1497 € per Diagnosis | |||||
|---|---|---|---|---|---|
| Sensitivity Analysis | First Alternative Assumption | Second Alternative Assumption | |||
| Parameter | Base Case Estimate | Lower Value | Cost per Diagnosis Variation | Upper Value | Cost per Diagnosis Variation |
| WES cost | 3670€ | 466€ | −3859€ | 6670€ | +586€ |
| Gene panel cost | 1646€ | 350€ | +281€ | 5060€ | −6109€ |
| Biopsy cost | 2198€ | 1480€ | −1139€ | 4366€ | −2583€ |
| Reverse phenotyping mean cost per patient | 115€ | 90€ | −1525€ | 230€ | −1341€ |
| Proportion of patients needing biopsy | 1 (for required cases) | 0.5 | −76€ | 0.7 | −177€ |
| Proportion of patients needing reverse phenotyping after WES | 0.2 | 0.1 | −1544€ | 0.4 | −1423€ |
| Proportion of patients with podocytopathies | 0.3 | 0.2 | −1032€ | 0.4 | −1980€ |
One-way sensitivity analysis shows how the results of the modeled analysis change using a range of values of each uncertain model parameter while holding other parameters fixed to their base case scenario. Base case estimate represents costs used in the modeled analysis. Lower and upper values represent the variations in costs of the base case parameter.
WES, whole-exome sequencing.