Figure 4.

Urea kinetics during different modalities of KRT. Urea kinetics are a suboptimal marker for assessing adequacy of KRT. However, current guidelines for adequacy of hemodialysis and CKRT utilize urea kinetics and Kt/V_urea. Standard Kt/V_urea (StdKt/V_urea) may be utilized to compare weekly clearances among different modalities. CKRT with an effluent flow rate of 20 ml/kg per hour provides StdKt/V_urea of 6 (assuming no interruptions of therapy), and intermittent HD, three times per week, with a single pool Kt/V_urea of 1.3 per treatment provides a weekly clearance of 2.0. PIKRT protocol at our institution usually provides a single pool Kt/V_urea of approximately 0.9 per session and, if given 6 days a week, will provide a weekly StdKt/V_urea of 3.5. Adapted from ref. 34, with permission.