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GRK4/GRK5 double knockouts are not born at Mendelian ratios
| Number of Mice | GRK4+/− GRK5+/− × GRK4+/− GRK5+/− | |
|---|---|---|
| Total | 136 | |
| Expected number/percentage | 8.5 | 6.25% |
| Actual number/percentage | 3 | 2.21% |
Mice lacking both GRK4 and GRK5 are not born at the expected Mendelian ratios. Offspring of double heterozygous matings should have yielded 6.25% double homozygotes, which is 8–9 mice of 136 in total. However, only three double homozygotes were born.
