Table 1.
Baseline characteristics by BMI groups
| Characteristics | BMI groups, kg/m2 | P-value | P for linear trend | |||
|---|---|---|---|---|---|---|
| < 18.5 | 18.5- < 23 | 23- < 27.5 | ≥ 27.5 | |||
| N, % | 309, 2.18% | 3855, 27.25% | 7491, 52.95% | 2491, 17.61% | ||
| Age (year), median (IQR) | 72 (61–78) | 65 (57–73) | 62 (54–69) | 60 (52–67) | < 0.0001 | < 0.0001 |
| Male, N (%) | 177 (57.28%) | 2599 (67.42%) | 5303 (70.79%) | 1641 (65.88%) | < 0.0001 | 0.2082 |
| Ethnicity(Han), N (%) | 299 (96.76%) | 3776 (97.95%) | 7268 (97.02%) | 2387 (95.82%) | < 0.0001 | < 0.0001 |
| Stroke history, N (%) | 80 (25.89%) | 806 (20.91%) | 1663 (22.20%) | 585 (23.48%) | 0.0361 | 0.1016 |
| Medical comorbidities, N ( %) | ||||||
| Diabetes mellitus | 41 (13.27%) | 760 (19.71%) | 1829 (24.42%) | 680 (27.30%) | < 0.0001 | < 0.0001 |
| Atrial fibrillation | 42 (13.59%) | 303 (7.86%) | 489 (6.53%) | 152 (6.10%) | < 0.0001 | < 0.0001 |
| Myocardial infarction | 10 (3.24%) | 69 (1.79%) | 144 (1.92%) | 55 (2.21%) | 0.2572 | 0.6764 |
| Hypertension | 159 (51.46%) | 2085 (54.09%) | 4835 (64.54%) | 1808 (72.58%) | < 0.0001 | < 0.0001 |
| Lipid metabolism disorders | 16 (5.18%) | 226 (5.86%) | 572 (7.64%) | 261 (10.48%) | < 0.0001 | < 0.0001 |
| Heavy drinkinga, N ( %) | 38 (12.30%) | 552 (14.32%) | 1075 (14.35%) | 345 (13.85%) | 0.7171 | 0.9632 |
| Current smoker, N ( %) | 99 (32.04%) | 1210 (31.39%) | 2411 (32.19%) | 783 (31.43%) | 0.8085 | 0.8819 |
| Waist circumference (cm), median (IQR)b | 72 (69–79) | 80 (75–86) | 87 (80–94) | 96.5 (88–105) | 0.0001 | < 0.0001 |
| TOAST subtypes, N (%) | ||||||
| Large-artery atherosclerosis | 78 (25.24%) | 992 (25.73%) | 1936 (25.84%) | 661 (26.54%) | 0.0016 | |
| Small-vessel occlusion | 52 (16.83%) | 790 (20.49%) | 1723 (23.00%) | 572 (22.96%) | ||
| Cardioembolism | 28 (9.06%) | 282 (7.32%) | 442 (5.90%) | 129 (5.18%) | ||
| Stroke of other determined etiology | 5 (1.62%) | 50 (1.30%) | 86 (1.15%) | 30 (1.20%) | ||
| Stroke of undetermined etiology | 146 (47.25%) | 1741 (45.16%) | 3304 (44.11%) | 1099 (44.12%) | ||
| NIHSS at admission, median (IQR) | 5 (2–9) | 4 (2–6) | 3 (2–6) | 3 (2–6) | < 0.0001 | < 0.0001 |
| Intravenous thrombolysis, N (%) | 55 (17.80%) | 465 (12.06%) | 751 (10.03%) | 249 (10.00%) | < 0.0001 | < 0.0001 |
| Arterial thrombolysis or mechanical thrombectomy, N (%) | 3 (0.97%) | 25 (0.65%) | 32 (0.43%) | 11 (0.44%) | 0.2573 | 0.096 |
Kruskal–Wallis test was used to compare group differences for continuous variables, and χ2 test was used for categorical variables. P for linear trend was calculated by Kendall's Tau-b correlation analysis for continuous variables or Cochran-Armitage test for categorical variables. aHeavy drinking was defined as alcohol consumption ≥ 2 standard alcohol consumption /day. bWaist circumference was available for 4805 patients. BMI, body mass index; TOAST, Trial of Org 10,172 in Acute Stroke Treatment; NIHSS, National Institutes of Health Stroke Scale