Table 3.
Association of BMI/WHtR with outcomes
| Number at risk | Number of events, N (%) | Unadjusted Hazard Ratio(95%CIa | P-value | Adjusted Hazard Ratio(95%CI) b | P-value | Pinteraction with stroke subtypec | |
|---|---|---|---|---|---|---|---|
| mortality | |||||||
| BMI groups, kg/m2 | 0.6751 | ||||||
| < 18.5 | 309 | 32 (10.36%) | 2.55 (1.75–3.73) | < 0.0001 | 1.70 (1.16–2.49) | 0.007 | |
| 18.5- < 23 | 3855 | 162 (4.20%) | 1.00 (Ref) | 1.00 (Ref) | |||
| 23- < 27.5 | 7491 | 235 (3.14%) | 0.74 (0.61–0.91) | 0.0035 | 0.94 (0.77–1.16) | 0.5779 | |
| ≥ 27.5 | 2491 | 57 (2.29%) | 0.54 (0.40–0.73) | < 0.0001 | 0.76 (0.56–1.03) | 0.0784 | |
| WHtR groups | 0.6714 | ||||||
| ≥ 0.57 | 1130 | 35 (3.10%) | 0.64 (0.43–0.97) | 0.0357 | 0.70 (0.46–1.07) | 0.0977 | |
| 0.52- < 0.57 | 1190 | 25 (2.10%) | 0.43 (0.27–0.68) | 0.0004 | 0.42 (0.26–0.67) | 0.0003 | |
| 0.47- < 0.52 | 1316 | 63 (4.79%) | 1.00 (Ref) | 1.00 (Ref) | |||
| < 0.47 | 1169 | 67 (5.73%) | 1.21 (0.86–1.71) | 0.2785 | 0.91 (0.64–1.29) | 0.5937 | |
| Recurrence of stroke | |||||||
| BMI groups, kg/m2 | 0.6263 | ||||||
| < 18.5 | 309 | 36 (11.65%) | 1.22 (0.87–1.72) | 0.2525 | 1.13 (0.80–1.59) | 0.5005 | |
| 18.5- < 23 | 3855 | 382 (9.91%) | 1.00 (Ref) | 1.00 (Ref) | |||
| 23- < 27.5 | 7491 | 741 (9.89%) | 1.00 (0.88–1.13) | 0.9329 | 1.03 (0.91–1.17) | 0.6484 | |
| ≥ 27.5 | 2491 | 265 (10.64%) | 1.07 (0.92–1.26) | 0.3709 | 1.13 (0.96–1.32) | 0.1499 | |
| WHtR groups | 0.9101 | ||||||
| ≥ 0.57 | 1130 | 132 (11.68%) | 1.07 (0.84–1.35) | 0.6012 | 1.10 (0.87–1.40) | 0.4345 | |
| 0.52- < 0.57 | 1190 | 101 (8.49%) | 0.76 (0.59–0.98) | 0.032 | 0.77 (0.60–0.99) | 0.0440 | |
| 0.47- < 0.52 | 1316 | 145 (11.02%) | 1.00 (Ref) | 1.00 (Ref) | |||
| < 0.47 | 1169 | 111 (9.50%) | 0.86 (0.67–1.10) | 0.2339 | 0.83 (0.65–1.07) | 0.1440 | |
| Combined vascular event | |||||||
| BMI groups, kg/m2 | 0.6467 | ||||||
| < 18.5 | 309 | 39 (12.62%) | 1.24 (0.90–1.73) | 0.1934 | 1.14 (0.82–1.58) | 0.4469 | |
| 18.5- < 23 | 3855 | 307 (10.56%) | 1.00 (Ref) | 1.00 (Ref) | |||
| 23- < 27.5 | 7491 | 784 (10.47%) | 0.99 (0.88–1.11) | 0.8354 | 1.02 (0.91–1.15) | 0.7288 | |
| ≥ 27.5 | 2491 | 275 (11.04%) | 1.05 (0.90–1.22) | 0.5664 | 1.10 (0.94–1.28) | 0.2474 | |
| WHtR groups | 0.8802 | ||||||
| ≥ 0.57 | 1130 | 140 (12.39%) | 1.04 (0.83–1.30) | 0.7576 | 1.07 (0.85–1.35) | 0.5679 | |
| 0.52- < 0.57 | 1190 | 107 (8.99%) | 0.74 (0.58–0.94) | 0.0194 | 0.75 (0.58–0.95) | 0.0198 | |
| 0.47- < 0.52 | 1316 | 158 (12.01%) | 1.00 (Ref) | 1.00 (Ref) | |||
| < 0.47 | 1169 | 115 (9.84%) | 0.82 (0.64–1.04) | 0.1005 | 0.79 (0.62–1.00) | 0.0511 | |
awere calculated using univariate COX proportional hazard models; bwere calculated using multivariable COX proportional hazard models adjusted for age, gender, ethnicity, history of diabetes mellitus, history of atrial fibrillation, history of hypertension, history of myocardial infarction, history of lipid metabolism disorders, heavy drinking, smoking, intravenous thrombolysis, arterial thrombolysis or mechanical thrombectomy, NIHSS at admission, TOAST subtypes. cPinteraction with stroke subtype, the interactions of BMI/WHtR with stroke subtype were investigated with the addition of BMI/WHtR by stroke subtype groups using multivariable Cox proportional hazards models. BMI body mass index, WHtR waist-to-height ratio, TOAST Trial of Org 10,172 in Acute Stroke Treatment, NIHSS National Institutes of Health Stroke Scale