Table 2.
Multivariate analysis of Dutch-cohort of TEAM for distant metastasis or death due to breast cancer (DM)
| Variable | DM a,c,d (total cohort) | |
|---|---|---|
| Hazard ratio (95% CI) | P value | |
| Tumor stage | ||
| T1 | Reference | – |
| T2-4 | 1.28 (0.85–1.93) | 0.31 |
| Lymph node status | ||
| Negative | Reference | – |
| Positive | 1.19 (0.75–1.88) | 0.54 |
| Histological grade | ||
| G1 | Reference | |
| G2 + 3 | 2.07 (1.00–4.27) | 0.10 |
| CAB risk category | ||
| Low-risk | Reference | – |
| High-risk | 2.54 (1.67–3.85) | < 0.001 b |
aModel undergone multivariate step-cox regression (both direction), adjusted for T stage (T2-4 vs T1), lymph nodal status (N+ vs N−), grade (G2 + 3 vs G1), and CAB risk score. Likelihood ratio was used to test whether the model was statistically significant. DM: distant metastasis or death due to breast cancer, CAB: CanAssist Breast. b P < 0.05. c Model likelihood ratio test = 24.59, P < 0.001. d There was only one patient who died due to breast cancer with only local recurrence, without distant metastasis