Table 1.
Flecainide concentration and time after dose in maternal blood, breastmilk and infant blood
| Date and Time | Time after dose (Hours)# | Flecainide concentration (mg/L) | Milk / plasma | ||
|---|---|---|---|---|---|
| Maternal blood | Breastmilk | Infant blood | |||
| January 26, 2021 (8:39AM) | 0.7 | 0.25 | |||
| February 1, 2021 (9:13AM) | 1.2 | 0.29 | |||
| February 9, 2021 (9:19AM) | 1.3 | 0.36 | |||
| February 12, 2021 (3:44PM) Delivery | 7.7 | 0.26* | |||
| February 13, 2021 (1:30PM) | 5.5 | 0.55 | |||
| February 16, 2021 (12:00PM) | 4.0 | 0.94 | |||
| February 19, 2021 (1:30PM) | 5.5 | 0.77 | |||
| February 22, 2021 (1:22PM) | 5.4 | < 0.05 | |||
| February 22, 2021 (1:58PM) | 6.0 | 0.41 | 0.94 | 2.3 | |
| February 25, 2021 (1:00PM) | 5.0 | 0.94 | |||
| March 1, 2021 (9:40AM) | 1.7 | 0.32 | 0.87 | 2.7 | |
| March 1, 2021 (10:23AM) | 2.4 | < 0.05 | |||
| March 8, 2021 (9:07AM) | 1.1 | 0.30 | 0.99 | 3.3 | |
| March 8, 2021 (9:30AM) | 1.5 | < 0.05 | |||
| March 15, 2021 (9:23AM) | 1.4 | 0.33 | |||
| April 12, 2021 (10:30AM) | 2.5 | 0.61 | |||
| April 12, 2021 (10:50AM) | 2.8 | < 0.05 | |||
| April 12, 2021 (11:54AM) | 3.9 | 0.36 | |||
| May 25, 2021 (10:44AM) | 2.7 | 0.53 | |||
| August 16, 2021 (9:48AM) | 1.8 | < 0.05 | |||
| August 16, 2021 (11:25AM) | 3.4 | 0.67 | |||
# Compared to daily flecainide administration at 8:00AM and 8:00PM.
* Blood collected from the umbilical cord after delivery