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. 2023 Apr 13;21:257. doi: 10.1186/s12967-023-04092-9

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Differences in response status by NanoString data. A Volcano plot of singscores based on the three singscore-calculating approaches. The red dots denote gene expression signatures (FDR ≤ 0.05) detailing the top 10 significant signatures. The y-axis is –log₁₀-transformed FDR. The x-axis is the difference in the median singscores between responders and non-responders. B Volcano plot of gene expressions from Advanced Analysis in nSolver4.0. The y-axis is –log₁₀-transformed adjusted p-values. The x-axis is log₂-transformed fold change. C The plots based on scores of 25 in-built pathways from Advanced Analysis in nSolver4.0. Each dot represents the centralized average scores in each signature in responders/non-responders. D Heatmap of 30 DEGs with adj. p-values ≤ 0.05 and |log₂FC|≥ 1. The color shows the log₂(count). E Heatmaps of scores of 13 significant in-built pathways with hierarchical clustering. The color indicates the pathway score

Fig. 2 — Differences in response status by NanoString data. A Volcano plot of singscores based on the three singscore-calculating approaches. The red dots denote gene expression signatures (FDR ≤ 0.05) detailing the top 10 significant signatures. The y-axis is –log₁₀-transformed FDR. The x-axis is the difference in the median singscores between responders and non-responders. B Volcano plot of gene expressions from Advanced Analysis in nSolver4.0. The y-axis is –log₁₀-transformed adjusted p-values. The x-axis is log₂-transformed fold change. C The plots based on scores of 25 in-built pathways from Advanced Analysis in nSolver4.0. Each dot represents the centralized average scores in each signature in responders/non-responders. D Heatmap of 30 DEGs with adj. p-values ≤ 0.05 and |log₂FC|≥ 1. The color shows the log₂(count). E Heatmaps of scores of 13 significant in-built pathways with hierarchical clustering. The color indicates the pathway score