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IOA-244 remodels the immune microenvironment and allow ICB-driven antitumor immune response. Flow cytometry analysis from CT26 tumors showing quantification of CD45+ cells (A), CD8/CD45 (B), CD4/CD45 (C), mMDSC/CD45 (D), gMDSC/CD45 (E). F and G, Efficacy of IOA-244 alone or combined with anti-PD-L1 in the LLC (H and I), A20 (H–I) and Pan-02 (J and K) syngeneic mouse tumor models, measuring tumor volumes. Statistics shown are two-way ANOVAs (Tukey multiple comparison test).
