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. Author manuscript; available in PMC: 2023 Apr 14.
Published in final edited form as: Nat Aging. 2022 Aug 16;2(8):704–713. doi: 10.1038/s43587-022-00268-y

Extended Data Fig. 1 |. Off-target effects of Visudyne do not contribute to behavioral response to peripheral IL-1β.

Extended Data Fig. 1 |

a, Schematic view of dorsal skull. Crosses mark the location of photoactivation with non-thermal laser. Off-target sites were chosen for their lack of meningeal vasculature. b, Locomotor activity one week following artificial cerebrospinal fluid (aCSF) and targeted photoablation, or Visudyne and off-target photoactivation. Mice were injected with 1 ug IL-1β or saline intraperitoneally 1 h before repeated open field assessment (n = 8 mice per group, 2 outliers removed in aCSF – IL-1b by ROUT Q = 0.5%). Data presented as mean ± s.e.m. b, Three-way ANOVA. Data in b resulted from a single experiment.