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. 2023 Mar 31;14:1142581. doi: 10.3389/fphar.2023.1142581

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Copyright © 2023 Cairns, Leonard, Khan, Parks, Maglennon, Zhang, Lazic, Ewart and David.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Treatment-induced lineage-specific toxicity. The effect of treatment with AZ1 or carboplatin on different haematopoietic lineages over time in BM-1, BM-2 or BM-3 studies. The shaded regions represent the dosing period in each case. Stars represent the results of the significance tests, at both the end of the dosing period and the end of the recovery period for each drug (note that carboplatin showed no significant effects at the end of the dosing period), Significance values are (<0.1), * (p < 0.05), ** (p < 0.01), *** (p < 0.001).